Clinical Products
AggRAM®
Advanced Modular System for Platelet Aggregation Ristocetin Cofactor
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002Helena offers the AggRAM for platelet aggregation and ristocetin cofactor testing. This compact instrument provides excellent precision, ease of use and flexibility. The AggRAM couples four-channel laser optic modules with a powerful Windows interface. Up to two modules can be run per Remote Analyzer computer, providing up to eight channels to handle your workload. Other features include:
    • Advanced Laser Optics using a Laser Diode allowing excellent precision
    • Powerful & User-Friendly Windows Software
    • Data Handling Features which automatically calculates slope and max % aggregation
    • Customized Reports
    • On Board Quality Control Functions
Cat. No. Item
1484 AggRAM Analyzer
1486 AggRAM Module
http://www.helena.com/aggram.html

Platelet Aggregation Reagents
005Platelet Aggregation Kit
Cat. No. Item
5369 Platelet Aggregation Kit
  ADP Reagent, 2 x 1 mL
  Collagen Reagent, 2 x 1 mL
  Epinephrine Reagent, 2 x 1 mL

The Platelet Aggregation Kit is used to identify normal and abnormal platelet function, to quantitate platelet response and to determine the patient's response to anti-platelet drug therapy. The reagents are optimized for use with the Helena AggRAM analyzer, but may be used on any turbidometric aggregometer of similar quality.
006ADP Reagent
Cat. No. Item
5366 ADP, 2 x 1 mL

ADP is a lyophilized preparation of adenosine-5-diphosphate. ADP is for use in routine platelet aggregation studies for the evaluation of qualitative platelet function disorders. The concentration of the reconstituted ADP reagent is 20 μM.


010Collagen Reagent
Cat. No. Item
5368 Collagen, 2 x 1 mL

The collagen reagent is a clear, stabilized liquid reagent prepared from equine tendon, which is one of the world's best collagen preparations. Collagen is used in routine platelet aggregation studies for evaluation of qualitative platelet function disorders. The collagen reagent stock solution is reconstituted to a concentration of 100 μg/mL.

007Epinephrine Reagent
Cat. No. Item
5367 Epinephrine, 2 x 1 mL

Epinephrine is a lyophilized preparation of L-epinephrine bitartrate. Epinephrine is for use in routine platelet aggregation studies for evaluation of qualitative platelet function disorders. After reconstitution, epinephrine concentration is 300 μM.

008Arachidonic Acid Reagent
Cat. No. Item
5364 Arachidonic Acid, 2 x 1 mL

Arachidonic Acid is a lyophilized preparation of sodium arachidonate for use in platelet aggregation studies of abnormal function, especially dysfunction induced by aspirin and aspirin-containing medications.


009Ristocetin (for Aggregation Assays)
Cat. No. Item
5199 Ristocetin, 10 x 0.5 mL

This Ristocetin is for use in platelet aggregation studies for confirmation of von Willebrand Disease (vWD) and Bernard-Soulier Syndrome. Normal platelet-rich plasma exhibits a positive aggregation response to the addition of ristocetin using a final concentration of 15 mg/mL. The majority of vWD patients exhibit a negative response to ristocetin as do Bernard-Soulier patients.
011Helena Ristocetin Cofactor Assay Kit
Cat. No. Item
5370 Ristocetin Cofactor Kit, 50 tests
  Lyophilized Platelets, 4 x 5.0 mL
  Ristocetin Cofactor Abnormal Control, 2 x 0.5 m
  S.A.R.P. Assayed Reference Plasma, 2 x 1.0 mL
  Helena Ristocetin - 10 mg/mL, 2 x 1.5 mL
  Tris-Buffered Saline, 1 x 35 mL

Ristocetin cofactor assays measure the ability of von Willebrand factor (Ristocetin cofactor) in the patient's plasma to agglutinate formalinized platelets in the presence of ristocetin. Decreased levels of ristocetin cofactor activity are associated with von Willebrand Disease.

014Lyophilized Platelets

Cat. No. Item
5356 Lyophilized Platelets, 5 x 10 mL
5371 Lyophilized Platelets, 5 x  5 mL

Lyophilized Platelets are a standardized suspension of fixed platelets derived from platelet concentrate. Lyophilized Platelets are for use in the quantitation of ristocetin cofactor activity in plasma. The platelets are lyophilized for stability. Tris-Buffered Saline (Cat. No. 5365) should be used for reconstitution. The concentration of the reconstituted platelet suspension is approximately 200,000/mL. Platelets in Cat. No. 5356 show a slower reaction rate.

015Ristocetin Cofactor Abnormal Control Plasma

Cat. No. Item
5373 Ristocetin Cofactor Abnormal Control, 5 x 0.5 mL

The control is to be used in the assay of ristocetin cofactor. It contains citrated human plasma with a level of ristocetin cofactor activity below 50%.

012Ristocetin - 10 mg/mL (for Ristocetin Cofactor Assays)

Cat. No. Item
5372 Ristocetin - 10 mg/mL, 5 x 1.5 mL

The reagent is to be used in the quantitative determination of ristocetin cofactor activity. The ristocetin reagent is prepared from Nocardia lurida and is used in the tests for von Willebrand Disease and Bernard-Soulier Syndrome.
013Tris-Buffered Saline

Cat. No. Item
5365 Tris-Buffered Saline, 1 x 125 mL

Tris-Buffered Saline is used for reconstitution and dilution of some of the reagents used in platelet aggregation assays and ristocetin cofactor assays.

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