|Helena offers the AggRAM for platelet aggregation and ristocetin cofactor testing. This compact instrument provides excellent precision, ease of use and flexibility. The AggRAM couples four-channel laser optic modules with a powerful Windows interface. Up to two modules can be run per Remote Analyzer computer, providing up to eight channels to handle your workload. Other features include:|
|Platelet Aggregation Kit|
The Platelet Aggregation Kit is used to identify normal and abnormal platelet function, to quantitate platelet response and to determine the patient's response to anti-platelet drug therapy. The reagents are optimized for use with the Helena AggRAM analyzer, but may be used on any turbidometric aggregometer of similar quality.
ADP is a lyophilized preparation of adenosine-5-diphosphate. ADP is for use in routine platelet aggregation studies for the evaluation of qualitative platelet function disorders. The concentration of the reconstituted ADP reagent is 20 μM.
The collagen reagent is a clear, stabilized liquid reagent prepared from equine tendon, which is one of the world's best collagen preparations. Collagen is used in routine platelet aggregation studies for evaluation of qualitative platelet function disorders. The collagen reagent stock solution is reconstituted to a concentration of 100 μg/mL.
Epinephrine is a lyophilized preparation of L-epinephrine bitartrate. Epinephrine is for use in routine platelet aggregation studies for evaluation of qualitative platelet function disorders. After reconstitution, epinephrine concentration is 300 μM.
Arachidonic Acid Reagent
Arachidonic Acid is a lyophilized preparation of sodium arachidonate for use in platelet aggregation studies of abnormal function, especially dysfunction induced by aspirin and aspirin-containing medications.
Ristocetin (for Aggregation Assays)
This Ristocetin is for use in platelet aggregation studies for confirmation of von Willebrand Disease (vWD) and Bernard-Soulier Syndrome. Normal platelet-rich plasma exhibits a positive aggregation response to the addition of ristocetin using a final concentration of 15 mg/mL. The majority of vWD patients exhibit a negative response to ristocetin as do Bernard-Soulier patients.
Helena Ristocetin Cofactor Assay Kit
Ristocetin cofactor assays measure the ability of von Willebrand factor (Ristocetin cofactor) in the patient's plasma to agglutinate formalinized platelets in the presence of ristocetin. Decreased levels of ristocetin cofactor activity are associated with von Willebrand Disease.
Lyophilized Platelets are a standardized suspension of fixed platelets derived from platelet concentrate. Lyophilized Platelets are for use in the quantitation of ristocetin cofactor activity in plasma. The platelets are lyophilized for stability. Tris-Buffered Saline (Cat. No. 5365) should be used for reconstitution. The concentration of the reconstituted platelet suspension is approximately 200,000/mL. Platelets in Cat. No. 5356 show a slower reaction rate.
Ristocetin Cofactor Abnormal Control Plasma
The control is to be used in the assay of ristocetin cofactor. It contains citrated human plasma with a level of ristocetin cofactor activity below 50%.
Ristocetin - 10 mg/mL (for Ristocetin Cofactor Assays)
The reagent is to be used in the quantitative determination of ristocetin cofactor activity. The ristocetin reagent is prepared from Nocardia lurida and is used in the tests for von Willebrand Disease and Bernard-Soulier Syndrome.
Tris-Buffered Saline is used for reconstitution and dilution of some of the reagents used in platelet aggregation assays and ristocetin cofactor assays.